Dr. Nathan Bryan

Dr. Nathan S. Bryan, PhD is an Adjunct Assistant Professor at Baylor College of Medicine in the Department of Molecular and Human Genetics. Prior to his work at Baylor, Dr. Bryan was an Assistant Professor of Molecular Medicine within the Brown Foundation Institute of Molecular Medicine, part of the School of Medicine at the University of Texas Health Science Center at Houston. 
He was also on faculty within the Department of Integrative Biology and Pharmacology and Graduate School of Biomedical Sciences at the UT Houston Medical School.

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute.

Dr. Bryan joined the Institute of Molecular Medicine, University of Texas Health Science Center in Houston, in June 2006 and is now part of the Texas Therapeutics Institute (TTI). TTI’s mission is to carry out translational research and drug discoveries related to cancer, cardiovascular disease and stem cells. He is an active member of the Nitric Oxide Society, Society for Free Radical Biology and Medicine, American Heart Association, American Diabetes Association, and American Physiological Society.

Dr. Bryan’s Research Philosophy

Dr. Bryan’s research is dedicated to providing a better understanding of the interactions of nitric oxide and related metabolites with their different biological targets at the molecular and cellular level and the significance of these reactions for physiology and patho-physiology. Attempts are made to identify what particular changes in N-O-related signaling pathways and reaction products occur in disease states such as endothelial dysfunction, ischemia/reperfusion, tissue/cardiac protection, diabetes, atherosclerosis and inflammation with the aim of testing their amenability as biomarkers for diagnosis and/or treatment of specific disease.
Current research is directed to understand the interactions of exogenous dietary nitrite/nitrate (NOx) on the endogenous NO/cGMP pathway and how perturbations in each system affect cardiovascular health.

Dr. Bryan is credited with several seminal discoveries in the nitric oxide field:

  1. Nitrite is a signaling molecule and regulator of gene expression. [1]
  2. Nitrite and nitrate are indispensable nutrients required for optimal cardiovascular health. [2]
  3. First to describe nitrite and nitrate as vitamins. [3]
  4. Discovered an endocrine function of nitric oxide. [4]
  5. Discovered natural product chemistry that can be used to safely and effectively generate and restore nitric oxide in humans.[5, 6]

Dr. Ernst Schwartz

Ernst R. Schwarz, M.D., Ph.D., is a clinical cardiologist and scientist, who is specializes in advanced heart failure, coronary artery disease, aging, and sexual dysfunction. Dr. Schwarz is attending cardiologist and Professor of Medicine at Cedars Sinai Medical Center in Los Angeles, as well as Clinical Professor of Medicine at UCLA. He is also the Medical Director of Pacific Heart Medical Group and Chairman of DMSI, Beverly Hills.

His primary clinical interests are end-stage heart failure, interventional cardiology, and sexual function. A clinician and scientist, Dr. Schwarz has presented and lectured all over the world. He has written more than 150 articles for peer-reviewed publications, eight book chapters on cardiovascular medicine, and three medical textbooks. He is also a member of numerous editorial boards of international, peer-reviewed scientific journals.

Dr. Schwarz earned his medical degree from Philipps-University in Marburg, Germany, receiving medical doctor titles from Philipps-University Marburg and from the University of Vienna, Austria. He received his doctorate from the University of Technology in Aachen, Germany. Dr. Schwarz is a trained cardiac interventionalist as well as board certified in internal medicine, cardiology/cardiovascular diseases, and advanced heart failure/transplant cardiology by the American Board of Internal Medicine.

Dr. John Ivy

Dr. John Ivy is the Teresa Lozano Long Endowed Chair Emeritus at the University of Texas at Austin. He received his Ph.D. in Exercise Physiology from the University of Maryland, and trained in physiology and metabolism at Washington University School of Medicine as an NIH Post-Doctoral Fellow. He has served on the faculty at the University of Texas for 31 years and as Chair of the Department of Kinesiology and Health Education for 13 years.
His research has pioneered our understanding of muscle metabolism and how nutritional supplementation can improve exercise performance, recovery and training adaptation. He has also researched the effects of exercise and nutrition on muscle glucose transport and insulin resistance, and how appropriate levels of physical activity and diet can prevent type 2 diabetes and other metabolic diseases.

Dr. Ivy is the author of over 170 scientific papers, numerous book chapters and four books on sports nutrition including the very popular Nutrient Timing, which has been published in 4 languages.

Dr. Ivy is a Fellow of the National Academy of Kinesiology, and the American College of Sports Medicine and a recipient of the College’s Citation Award. He is also a member of the American Physiological Society and the American College of Nutrition.

Carolyn Pierini

Carolyn Pierini is a California licensed Clinical Laboratory Scientist and Medical Microbiologist with more than 20 years in the hospital laboratory departments of chemistry, hematology, immunology, R&D, and in particular, microbiology at St. Joseph Hospital/Children’s Hospital, in Orange, California. She has also been consultant / formulator for several nutritional supplement companies and has helped develop techniques for identifying nutritional needs through blood chemistry patterns.

She has authored numerous technical articles and professional materials for health care providers, has been a technical adviser to doctors, educational webinar host, TV and radio guest panelist, lecturer and formulation consultant.






Bryan, N.S., et al., Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol, 2005. 1(5): p. 290-7.


Hord, N.G., Y. Tang, and N.S. Bryan, Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr, 2009. 90(1): p. 1-10.


Bryan, N.S., Cardioprotective actions of nitrite therapy and dietary considerations. Front Biosci, 2009. 14: p. 4793-808.


Elrod, J.W., et al., Nitric oxide promotes distant organ protection: Evidence for an endocrine role of nitric oxide. Proc Natl Acad Sci U S A, 2008. 105(32): p. 11430-11435.


Nagamani, S.C., et al., Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet, 2012. 90(5): p. 836-46.


Zand, J., et al., All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans. Nutr Res, 2011. 31(4): p. 262-9.